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Progress in Application of Metagenomic Next-Generation Sequencing in Diagnosis and Treatment of Periprosthetic Knee Joint Infection

Received: 30 April 2023     Accepted: 15 May 2023     Published: 22 May 2023
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Abstract

Background: With the development of total knee arthroplasty, patients benefit from the occurrence of postoperative complications that affect the efficacy of the procedure. Among them, periprosthetic knee joint infection is a catastrophic complication of total knee arthroplasty, which is more difficult to diagnose and treat in the clinic and has low patient satisfaction. The ability to clearly diagnose and identify the pathogen at an early stage is an important guide to treatment and is the key to successful treatment. Objective: Traditional detection techniques have the disadvantages of low detection rate, complicated operation and time consuming in the detection of pathogens in periprosthetic knee joint infection, which are difficult to meet the needs of disease detection. Metagenomic next-generation sequencing technology is used to extract the genetic material of pathogens in samples and combine with high-throughput sequencing technology and bioinformatics analysis for detection, which has the advantages of efficient, accurate and sensitive detection of pathogens. Conclusion: Metagenomic next-generation sequencing technology has high application value in the diagnosis and treatment of infectious diseases, and its application in the field of periprosthetic knee joint infection is becoming more and more widespread, and the application of this technology in the diagnosis and treatment of periprosthetic knee joint infection is reviewed.

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 9, Issue 3)
DOI 10.11648/j.ijcems.20230903.13
Page(s) 52-59
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Metagenomic Next-Generation Sequencing, Periprosthetic Knee Joint Infection, Pathogen

References
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Cite This Article
  • APA Style

    Xiqi Zhang, Fengsheng Li. (2023). Progress in Application of Metagenomic Next-Generation Sequencing in Diagnosis and Treatment of Periprosthetic Knee Joint Infection. International Journal of Clinical and Experimental Medical Sciences, 9(3), 52-59. https://doi.org/10.11648/j.ijcems.20230903.13

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    ACS Style

    Xiqi Zhang; Fengsheng Li. Progress in Application of Metagenomic Next-Generation Sequencing in Diagnosis and Treatment of Periprosthetic Knee Joint Infection. Int. J. Clin. Exp. Med. Sci. 2023, 9(3), 52-59. doi: 10.11648/j.ijcems.20230903.13

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    AMA Style

    Xiqi Zhang, Fengsheng Li. Progress in Application of Metagenomic Next-Generation Sequencing in Diagnosis and Treatment of Periprosthetic Knee Joint Infection. Int J Clin Exp Med Sci. 2023;9(3):52-59. doi: 10.11648/j.ijcems.20230903.13

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  • @article{10.11648/j.ijcems.20230903.13,
      author = {Xiqi Zhang and Fengsheng Li},
      title = {Progress in Application of Metagenomic Next-Generation Sequencing in Diagnosis and Treatment of Periprosthetic Knee Joint Infection},
      journal = {International Journal of Clinical and Experimental Medical Sciences},
      volume = {9},
      number = {3},
      pages = {52-59},
      doi = {10.11648/j.ijcems.20230903.13},
      url = {https://doi.org/10.11648/j.ijcems.20230903.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20230903.13},
      abstract = {Background: With the development of total knee arthroplasty, patients benefit from the occurrence of postoperative complications that affect the efficacy of the procedure. Among them, periprosthetic knee joint infection is a catastrophic complication of total knee arthroplasty, which is more difficult to diagnose and treat in the clinic and has low patient satisfaction. The ability to clearly diagnose and identify the pathogen at an early stage is an important guide to treatment and is the key to successful treatment. Objective: Traditional detection techniques have the disadvantages of low detection rate, complicated operation and time consuming in the detection of pathogens in periprosthetic knee joint infection, which are difficult to meet the needs of disease detection. Metagenomic next-generation sequencing technology is used to extract the genetic material of pathogens in samples and combine with high-throughput sequencing technology and bioinformatics analysis for detection, which has the advantages of efficient, accurate and sensitive detection of pathogens. Conclusion: Metagenomic next-generation sequencing technology has high application value in the diagnosis and treatment of infectious diseases, and its application in the field of periprosthetic knee joint infection is becoming more and more widespread, and the application of this technology in the diagnosis and treatment of periprosthetic knee joint infection is reviewed.},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Progress in Application of Metagenomic Next-Generation Sequencing in Diagnosis and Treatment of Periprosthetic Knee Joint Infection
    AU  - Xiqi Zhang
    AU  - Fengsheng Li
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    N1  - https://doi.org/10.11648/j.ijcems.20230903.13
    DO  - 10.11648/j.ijcems.20230903.13
    T2  - International Journal of Clinical and Experimental Medical Sciences
    JF  - International Journal of Clinical and Experimental Medical Sciences
    JO  - International Journal of Clinical and Experimental Medical Sciences
    SP  - 52
    EP  - 59
    PB  - Science Publishing Group
    SN  - 2469-8032
    UR  - https://doi.org/10.11648/j.ijcems.20230903.13
    AB  - Background: With the development of total knee arthroplasty, patients benefit from the occurrence of postoperative complications that affect the efficacy of the procedure. Among them, periprosthetic knee joint infection is a catastrophic complication of total knee arthroplasty, which is more difficult to diagnose and treat in the clinic and has low patient satisfaction. The ability to clearly diagnose and identify the pathogen at an early stage is an important guide to treatment and is the key to successful treatment. Objective: Traditional detection techniques have the disadvantages of low detection rate, complicated operation and time consuming in the detection of pathogens in periprosthetic knee joint infection, which are difficult to meet the needs of disease detection. Metagenomic next-generation sequencing technology is used to extract the genetic material of pathogens in samples and combine with high-throughput sequencing technology and bioinformatics analysis for detection, which has the advantages of efficient, accurate and sensitive detection of pathogens. Conclusion: Metagenomic next-generation sequencing technology has high application value in the diagnosis and treatment of infectious diseases, and its application in the field of periprosthetic knee joint infection is becoming more and more widespread, and the application of this technology in the diagnosis and treatment of periprosthetic knee joint infection is reviewed.
    VL  - 9
    IS  - 3
    ER  - 

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Author Information
  • Department of Orthopedics, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China

  • Department of Orthopedics, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China

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