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Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment

Received: 6 September 2019     Accepted: 24 September 2019     Published: 17 October 2019
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Abstract

A well-defined group of patients of a German Fertility Centre, all supplemented periconceptually with omega-3-fatty acids, was monitored for specific alterations in the immunological laboratory status in correlation with the outcome of in-vitro-fertilization-(IVF)-treatment. For 36 of 52 IVF-patients IVF-treatment was successful. Patients with IVF-success revealed statistically significant lower soluble interleukin-2-receptor concentrations than unsuccessfully treated patients. Decreased numbers of CD4-positive T-cells could be correlated with increased failure rates of IVF, increased numbers of regulatory T-cells on the other hand with significantly improved success rates. Six of the parameters analyzed (T-lymphocytes, T-helper cells, B-lymphocytes, CD4/CD8 ratio and both classes of regulatory T-cells) significantly more often were below the median of the respective distribution in patients without IVF-success than in successfully treated. These results offer the possibility of developing a simple prognostic measure for the outcome of an IVF-therapy by assessing these parameters in relation to the median of the respective distribution. With increasing numbers of parameters lying below the median, the probability of successful IVF-treatment is decreasing.

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 5, Issue 5)
DOI 10.11648/j.ijcems.20190505.13
Page(s) 70-79
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Omega-3-Fatty Acid Supplementation, In Vitro Fertilization, Immunological Laboratory Status

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    Arasch Bareksei, Gerd Hafner, Sebastian Pfeiffer, Kathrin Schlatterer. (2019). Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment. International Journal of Clinical and Experimental Medical Sciences, 5(5), 70-79. https://doi.org/10.11648/j.ijcems.20190505.13

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    Arasch Bareksei; Gerd Hafner; Sebastian Pfeiffer; Kathrin Schlatterer. Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment. Int. J. Clin. Exp. Med. Sci. 2019, 5(5), 70-79. doi: 10.11648/j.ijcems.20190505.13

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    AMA Style

    Arasch Bareksei, Gerd Hafner, Sebastian Pfeiffer, Kathrin Schlatterer. Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment. Int J Clin Exp Med Sci. 2019;5(5):70-79. doi: 10.11648/j.ijcems.20190505.13

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  • @article{10.11648/j.ijcems.20190505.13,
      author = {Arasch Bareksei and Gerd Hafner and Sebastian Pfeiffer and Kathrin Schlatterer},
      title = {Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment},
      journal = {International Journal of Clinical and Experimental Medical Sciences},
      volume = {5},
      number = {5},
      pages = {70-79},
      doi = {10.11648/j.ijcems.20190505.13},
      url = {https://doi.org/10.11648/j.ijcems.20190505.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20190505.13},
      abstract = {A well-defined group of patients of a German Fertility Centre, all supplemented periconceptually with omega-3-fatty acids, was monitored for specific alterations in the immunological laboratory status in correlation with the outcome of in-vitro-fertilization-(IVF)-treatment. For 36 of 52 IVF-patients IVF-treatment was successful. Patients with IVF-success revealed statistically significant lower soluble interleukin-2-receptor concentrations than unsuccessfully treated patients. Decreased numbers of CD4-positive T-cells could be correlated with increased failure rates of IVF, increased numbers of regulatory T-cells on the other hand with significantly improved success rates. Six of the parameters analyzed (T-lymphocytes, T-helper cells, B-lymphocytes, CD4/CD8 ratio and both classes of regulatory T-cells) significantly more often were below the median of the respective distribution in patients without IVF-success than in successfully treated. These results offer the possibility of developing a simple prognostic measure for the outcome of an IVF-therapy by assessing these parameters in relation to the median of the respective distribution. With increasing numbers of parameters lying below the median, the probability of successful IVF-treatment is decreasing.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment
    AU  - Arasch Bareksei
    AU  - Gerd Hafner
    AU  - Sebastian Pfeiffer
    AU  - Kathrin Schlatterer
    Y1  - 2019/10/17
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ijcems.20190505.13
    DO  - 10.11648/j.ijcems.20190505.13
    T2  - International Journal of Clinical and Experimental Medical Sciences
    JF  - International Journal of Clinical and Experimental Medical Sciences
    JO  - International Journal of Clinical and Experimental Medical Sciences
    SP  - 70
    EP  - 79
    PB  - Science Publishing Group
    SN  - 2469-8032
    UR  - https://doi.org/10.11648/j.ijcems.20190505.13
    AB  - A well-defined group of patients of a German Fertility Centre, all supplemented periconceptually with omega-3-fatty acids, was monitored for specific alterations in the immunological laboratory status in correlation with the outcome of in-vitro-fertilization-(IVF)-treatment. For 36 of 52 IVF-patients IVF-treatment was successful. Patients with IVF-success revealed statistically significant lower soluble interleukin-2-receptor concentrations than unsuccessfully treated patients. Decreased numbers of CD4-positive T-cells could be correlated with increased failure rates of IVF, increased numbers of regulatory T-cells on the other hand with significantly improved success rates. Six of the parameters analyzed (T-lymphocytes, T-helper cells, B-lymphocytes, CD4/CD8 ratio and both classes of regulatory T-cells) significantly more often were below the median of the respective distribution in patients without IVF-success than in successfully treated. These results offer the possibility of developing a simple prognostic measure for the outcome of an IVF-therapy by assessing these parameters in relation to the median of the respective distribution. With increasing numbers of parameters lying below the median, the probability of successful IVF-treatment is decreasing.
    VL  - 5
    IS  - 5
    ER  - 

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Author Information
  • Dental Concept, Voerde, Germany

  • Institut Für Laboratoriumsmedizin, Mikrobiologie Und Hygiene, Evangelisches Klinikum Bethel, Bielefeld, Germany

  • Labor Todorov, Düsseldorf, Germany

  • Departments of Dermatology, Venereology, Allergology and Immunology, Brandenburg Medical School Theodor Fontane, Dessau, Germany

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