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Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial

Received: 8 March 2016     Accepted: 11 March 2016     Published: 25 April 2016
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Abstract

Glucan is the most studied immunomodulator. Among its properties, effects on cancer are the closest to clinical use. In our study, we evaluated the effects of short-term supplementation with glucan on NK cells in patients recovering from different types of cancer treatment. NK cells represent a distinct sub-population of lymphocytes endowed with the capacity to kill tumor cells without prior sensitization and form one of the most important defense mechanisms against cancer. To measure the numbers of NK cells, flow cytometer measuring four colors was used. Using a double-blind, placebo-controlled clinical trial, we found that adding glucan to the diet strongly increased the number of NK cells in blood.

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 2, Issue 2)
DOI 10.11648/j.ijcems.20160202.12
Page(s) 26-30
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Cancer, Glucan, NK Cells, Immunity, Lymphocytes

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Cite This Article
  • APA Style

    Josef Richter, Vlastimil Kral, Jitka Pohorska, Lucie Rajnohova Dobiasova, Vaclav Vetvicka. (2016). Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial. International Journal of Clinical and Experimental Medical Sciences, 2(2), 26-30. https://doi.org/10.11648/j.ijcems.20160202.12

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    ACS Style

    Josef Richter; Vlastimil Kral; Jitka Pohorska; Lucie Rajnohova Dobiasova; Vaclav Vetvicka. Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial. Int. J. Clin. Exp. Med. Sci. 2016, 2(2), 26-30. doi: 10.11648/j.ijcems.20160202.12

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    AMA Style

    Josef Richter, Vlastimil Kral, Jitka Pohorska, Lucie Rajnohova Dobiasova, Vaclav Vetvicka. Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial. Int J Clin Exp Med Sci. 2016;2(2):26-30. doi: 10.11648/j.ijcems.20160202.12

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  • @article{10.11648/j.ijcems.20160202.12,
      author = {Josef Richter and Vlastimil Kral and Jitka Pohorska and Lucie Rajnohova Dobiasova and Vaclav Vetvicka},
      title = {Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial},
      journal = {International Journal of Clinical and Experimental Medical Sciences},
      volume = {2},
      number = {2},
      pages = {26-30},
      doi = {10.11648/j.ijcems.20160202.12},
      url = {https://doi.org/10.11648/j.ijcems.20160202.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20160202.12},
      abstract = {Glucan is the most studied immunomodulator. Among its properties, effects on cancer are the closest to clinical use. In our study, we evaluated the effects of short-term supplementation with glucan on NK cells in patients recovering from different types of cancer treatment. NK cells represent a distinct sub-population of lymphocytes endowed with the capacity to kill tumor cells without prior sensitization and form one of the most important defense mechanisms against cancer. To measure the numbers of NK cells, flow cytometer measuring four colors was used. Using a double-blind, placebo-controlled clinical trial, we found that adding glucan to the diet strongly increased the number of NK cells in blood.},
     year = {2016}
    }
    

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    T1  - Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial
    AU  - Josef Richter
    AU  - Vlastimil Kral
    AU  - Jitka Pohorska
    AU  - Lucie Rajnohova Dobiasova
    AU  - Vaclav Vetvicka
    Y1  - 2016/04/25
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    N1  - https://doi.org/10.11648/j.ijcems.20160202.12
    DO  - 10.11648/j.ijcems.20160202.12
    T2  - International Journal of Clinical and Experimental Medical Sciences
    JF  - International Journal of Clinical and Experimental Medical Sciences
    JO  - International Journal of Clinical and Experimental Medical Sciences
    SP  - 26
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    PB  - Science Publishing Group
    SN  - 2469-8032
    UR  - https://doi.org/10.11648/j.ijcems.20160202.12
    AB  - Glucan is the most studied immunomodulator. Among its properties, effects on cancer are the closest to clinical use. In our study, we evaluated the effects of short-term supplementation with glucan on NK cells in patients recovering from different types of cancer treatment. NK cells represent a distinct sub-population of lymphocytes endowed with the capacity to kill tumor cells without prior sensitization and form one of the most important defense mechanisms against cancer. To measure the numbers of NK cells, flow cytometer measuring four colors was used. Using a double-blind, placebo-controlled clinical trial, we found that adding glucan to the diet strongly increased the number of NK cells in blood.
    VL  - 2
    IS  - 2
    ER  - 

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Author Information
  • Health Institute (Zdravotni ustav se sidlem) of Usti nad Labem, Usti nad Labem, Czech Republic

  • Health Institute (Zdravotni ustav se sidlem) of Usti nad Labem, Usti nad Labem, Czech Republic

  • Health Institute (Zdravotni ustav se sidlem) of Usti nad Labem, Usti nad Labem, Czech Republic

  • Health Institute (Zdravotni ustav se sidlem) of Usti nad Labem, Usti nad Labem, Czech Republic

  • University of Louisville, Department of Pathology, Louisville, KY, USA

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